Articles
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Xanthine bladder stones are an uncommon type of urinary stone that can occur in both dogs and cats. Xanthine is produced when purines (a component of animal proteins) are broken down within the body. Most dogs can further break down xanthine into other substances that are easily excreted, but some dogs are deficient in an enzyme that is required for this breakdown to occur. These dogs develop elevated levels of xanthine in the urine, resulting in xanthine stones forming within the urinary tract. They can also form secondary to administration of a medication called Allopurinol. Xanthine urinary tract stones are typically removed surgically. Affected dogs require long-term care with specialized diets to prevent recurrence.
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Zinc gluconate (neutralized) topical (brand name Maxi/Guard®Zn7 Derm) is an anti-irritant that may provide relief from the dry skin and itching associated with irritating skin conditions in cats, dogs, and other animals. Zinc gluconate (neutralized) topical comes in gel and liquid spray forms.
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Zinc-responsive dermatosis in dogs is a skin condition that results from zinc deficiency in the body. The deficiency can be due to an inability to adequately absorb zinc from the diet (most commonly seen in arctic breeds), zinc binders in dietary supplements, excess calcium (juvenile large breeds) or less commonly, an inadequate amount of zinc in the diet. Clinical signs include crusts and scaling around the eyes, mouth, scrotum and muco-cutaneous junctions. The haircoat can also, be dry and dull. Lethargy, inappetence, and lymphadenopathy may also occur. Diagnosis includes a history and physical exam and a skin biopsy. Treatment may include zinc supplementation, dietary change and ensuring a dog isn’t receiving any supplements that will interfere with zinc absorption.
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Zonisamide is an off-label, oral, systemic medication used to treat seizures alone or with other anticonvulsants. Side effects include sedation, uncoordinated walking, inappetence, liver disease, urinary stones, and metabolic acidosis. It is contraindicated in patients with liver disease or in pregnant or breeding animals.
